Experimental Magnesium Depletion **†

Observations in experimental magnesium depletion.

Normal urine concentrating ability in magnesium depletion.

1. We studied urine concentrating ability in ten magnesium-depleted puppies and compared the results with those of match-fed, littermate controls. 2. The experimental puppies became hypomagnesaemic and hypocalcaemic without evidence of potassium depletion. After 24 h of food and water deprivation, urine osmolality increased to 1350k 340 mosm/kg of water. This value did not differ from that of c...

Magnesium interrelationships in ischemic heart disease: a review.

Magnesium ions are essential for the maintenance of the functional and structural integ· rity of the myocardium. Experimental magnesium deficiency induces cardiac necrosis and enhances susceptibility to cardiotoxic agents; magnesium administration is protective. Recent investigations indicate that cellular loss of magnesium may be a basic biochemical mechanism in the evolution of myocardial les...

Dietary magnesium depletion affects metabolic responses during submaximal exercise in postmenopausal women.

Magnesium is an essential mineral that is required for optimal biological function including energy metabolism. Although national nutritional surveys indicate that usual magnesium intakes do not meet recommendations, particularly among older women, diet-induced magnesium depletion is considered rare among humans without concurrent illness. We examined the effects of dietary magnesium restrictio...

DISEASE OF THE MONTH Hypomagnesemia

Signs and Symptoms of Magnesium Depletion Symptomatic magnesium depletion is often associated with multiple biochemical abnormalities such as hypokalemia, hypocalcemia, and metabolic alkalosis. As a result, it is often difficult to ascribe specific clinical manifestations solely to hypomagnesemia. In 1960, five patients were reported with symptoms considered to be typical of magnesium depletion...